Genetic detection of T2D sub-phenotypes could be useful to personalize screening and care. James B.
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This article does not contain any studies with human or animal subjects performed by any of the authors. Skip to main content. Advertisement Hide. Current Diabetes Reports August , Cite as. Part of the following topical collections: Topical Collection on Diabetes Epidemiology. Purpose of Review Genome-wide association studies have delineated the genetic architecture of type 2 diabetes. Recent Findings Over genomic variants associated with T2D and its related quantitative traits are now known.
Summary Genomic polygenic scores for T2D can predict incident diabetes but may not be useful to improve health overall. This is a preview of subscription content, log in to check access. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.
Genetics of type 2 diabetes. Bethesda: National Institutes of Health; Google Scholar. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet.
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Supplementary Figure 10 shows the distribution of a genomic polygenic score for T2D in individuals of European ancestry. CrossRef Google Scholar. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. The genetic architecture of type 2 diabetes. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycemic traits to their downstream effectors.
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. Nat Commun. The genetic regulatory signature of type 2 diabetes in human skeletal muscle. A type 2 diabetes-associated functional regulatory variant in a pancreatic islet enhancer at the ADCY5 locus. A common type 2 diabetes risk variant potentiates activity of an evolutionarily conserved islet stretch enhancer and increases C2CD4A and C2CD4B expression. Am J Hum Genet. Human pancreatic beta cell lncRNAs control cell-specific regulatory networks.
Cell Metab. Genes Dev. Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
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Flannick J, Florez JC. Type 2 diabetes: genetic data sharing to advance complex disease research.
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Hum Mol Genet. A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications
Alert Subscription. DOI: Recommend this eBook to your Library. This e-book on diabetes epidemiology starts with the evolution in the diagnostic criteria for diabetes, particularly the changes in the last 15 years and their impact on the prevalence of the disease. The rationale for a diabetes screening program, recent development in screening strategies and screening tools are thoroughly reviewed and presented. Because obesity is one of the major risk factors for diabetes and has been included in several risk assessment questionnaires, the obesity-diabetes association is particularly addressed in this e-book.
The diagnostic cut-off value for surrogate measurement of body fat mass such as body mass index BMI and waist circumference is also discussed. The measurement errors and the strength of the association of diabetes with BMI and waist circumference are formally compared. Other diabetes related metabolic disorders such as dyslipidemia and hyperuricemia are also discussed with regard to their association with different degree of glucose intolerance including pre-diabetes and undiagnosed diabetes.
The risk of dyslipidemia with cardiovascular mortality and morbidity in people with different glucose levels is estimated within different ethnic groups and the ethnic differences are compared. Recent interest on diabetes-cancer association is on the rise. Academic literature on this issue presented in this volume.
The relationship of diabetes with cardiovascular disease is also recognised. In this book the focus is set on the impact of various levels of fasting and 2-hout post-load glucose on the occurrence of cardiovascular mortality and morbidity. Evolution of Diagnostic Criteria for Type 2 Diabetes. Prevalence of Type 2 Diabetes. Screening for Type 2 Diabetes.